吳世雄 先生
【研究領域】
．糖質化學及生物學
．細菌基因體及磷酸蛋白質體
．蛋白質化學
．本土真菌二次代謝物研究
【學歷】
．1975 年臺灣大學植物學學士
．1977 年臺灣大學生化學碩士
．1987 年威斯康辛大學藥學院博士
【經歷】
．1978/02至1979/02 汎球藥理研究所 醱酵組組長
．1979/03至1988/03中央研究院生物化學研究所助理研究員
．1988/04至1991/06中央研究院生物化學研究所副研究員
．1991/07至2008/07中央研究院生物化學研究所研究員
．1992至今臺灣大學生化科學所合聘教授
．2008至今中研院特聘研究員
．2009至今臺灣大學化學系合聘教授
【行政經歷】
．1998/06 – 1999/05台灣生化及分生學會秘書長
．1997/10- 1999/10中研院生化所副所長
．2002/01 – 2007/06中研院總辦事處學術事務組主任
．2007/07 – 2012/08中研院生化所副所長
．財團法人台北市醣質科學研究教育基金會執行董事 (2004 – 2012)及董事長(2013 – now)
【榮譽】
．1993 年國科會生物處傑出獎
．2003 年國科會自然處化學組傑出獎
．2008-2011 年國科會自然處傑出研究計畫
．2015年獲得王民寧獎(藥學)
【代表著作】
- Alan Y-L. Lee, C. H. Hsu, S-H. Wu* (2004) Functional Domains of Brevibacillus thermoruber Lon Protease for Oligomerization and DNA-binding: Role of Amino-Terminal and SSD Domains. J. Biol, Chem. 279, 34903-34912.
- C-P. Lu, C-T Ren, Y-N. Lai, S-H. Wu*, W-M. Wang, J-Y. Chen, and L-C. Lo* (2005) Design a Mechanism-Based Probe for Neuraminidase to Capture Influenza Virus. Angew. Chem. Int. Ed. Engl. 44: 6888-6892.
- C-H. Hsu, C. Chen, M-L. Jou, A. Y-L. Lee, Y-C. Lin, Y-P. Yu, W-T. Huang , S-H. Wu* (2005) Structural and DNA-binding Studies on the Bovine Antimicrobial Peptide, Indolicidin: Evidence for Multiple Conformations Involved in Binding to Membranes and DNA. Nucleic Acids Res. 33: 4053-4064.
- Y-L. Yang, C-P. Lu, M-Y. Chen, Kuei-Yu Chen, Y-C. Wu, and S-H. Wu* (2007) Cytotoxic Polyketides Containing Tetramic Acid Moieties Isolated from the Fungus Myceliophthora thermophila: Elucidation of the Relationship between Cytotoxicity and Stereoconfiguration. Chem. Eur. J. 13: 6985-6991.
- Y-L. Yang, W-Y. Liao, W-Y. Liu, C-C. Liaw, C-N. Shen, Z-Y. Huang, and S-H. Wu* (2009) Discovery of New Natural Products by Intact-cell Mass Spectrometry and LC-SPE-NMR–Malbranpyrroles, Novel Polyketides from Thermophilic Fungus Malbranchea sulfurea. Chem Eur. J. 15, 11573-11580.
- M-H. Lin, T-L. Hsu, S-Y. Lin, Y-J. Pan, J-T. Jan, J-T. Wang, K-H. Khoo, S-H. Wu* (2009) Phosphoproteomics of Klebsiella pneumoniae NTUH-K2044 reveals a tight link between tyrosine phosphorylation and virulence. Mol. Cell. Proteomics 8, 2613-2623.
- F-L. Yang, Y-L. Yang, P-C. Liao, J-C. Chou, K-C. Tsai, A-S. Yang, F. Sheu, T-L. Lin, P-F. Hsieh, J-T. Wang, K-F. Hua*, S-H. Wu* (2011) Structure and immunological characterization of the capsular polysaccharide of a pyrogenic liver abscess Klebsiella pneumoniae: activation of macrophages through Toll-like receptor 4. J. Biol. Chem. 286, 21041-21051.
- M-H. Lin, Y-L. Yang, Y-P. Chen, K-F. Hua, C-P. Lu, F. Sheu, G-H. Lin , S-S. Tsay, S-M. Liang*, S-H. Wu* (2011) A novel exopolysaccharide from the biofilm of Thermus aquaticus YT-1 induces the Immune response through toll-like receptor 2. J. Biol. Chem. 286, 17736-17745.
- J-H. Liao, C-S. Chen, C-C. Hu, W-T. Chen, S-P. Wang, I-L. Lin, Y-H. Huang, M-H. T-H. Wu*, F-Y. Huang*, S-H. Wu* (2011) Ditopic Complexation of Selenite Anions or Calcium Cations by Pirenoxine: An Implication for Anti-Cataractogenesis. Inorg. Chem. 50, 365-377.
- C-C. Liaw*, W-Y. Liao, C-S. Chen, S-C. Jao, Y-C. Wu, C-N. Shen*, S-H. Wu* (2011) Calcium-Chelating Capability of Tetrahydrofuranic Moieties Modulates Cytotoxicity of Annonaceous Acetogenins. Angew. Chem. Int. Ed. Engl 50, 7885-7891.
- C-C. Liaw*, Y-L. Yang, C-K. Lin, J-C. Lee, W-Y. Liao, C-N. J-H. Sheu, S-H. Wu* (2015) New Meroterpenoids from Aspergillus terreus with Inhibition of Cyclooxygenase-2 Expression. Org. Lett. 17, 2330-2333.
- J-H. Liao, T-H. Wu, M-Y. Chen, W-T. Chen, S-Y. Lu, Y-H. Wang, S-P. Wang, Y-M. Hsu, Y-S. Huang, Z-Y. Huang, Y-C. Lin, C-M. Chang, F-Y. Huang* & S-H. Wu* (2015) The Comparative Studies of Binding Activity of Curcumin and Didemethylated Curcumin with Selenite: Hydrogen Bonding vs Acid-Base Interactions. Scientific Reports, 5:17614 (DOI: 10.1038/srep17614)
- C-M. Chang, J. Chern, M-Y. Chen, K-F. Huang, C-H. Chen, Y-L. Yang, S-H. Wu*(2015) Avenaciolides: Potential MurA-Targeted Inhibitors Against Peptidoglycan Biosynthesis in Methicillin-Resistant Staphylococcus aureus (MRSA). J. Am. Chem. Soc. 137, 267−
- J-H. Lai, J-T. Yang, Jeffy Chern, T-L. Chen, W-L. Wu, J-H. Liao, S-F. Tsai, S-Y. Liang, C-C. Chou, S-H. Wu* (2016) Comparative phosphoproteomics reveals the role of AmpC β-lactamase phosphorylation in the clinical imipenem-resistant strain Acinetobacter baumannii SK17. Mol. Cell. Proteomics 15(1) 12-25.
- J-H. Liao, C-T. Henry Chien, H-Y. Wu, K-F. Huang, Iren Wang, M-R.Ho, I-F. Tu, I-M. Lee, W. Li, Y-L. Shih, C-Y. Wu, P. A. Lukyanov, S-T. Danny Hsu*, S-H. Wu* (2016) A Multivalent Marine Lectin from Crenomytilus grayanus Possesses Anti-cancer Activity through Recognizing Globotriose Gb3. J. Am. Chem. Soc. 138, 4787–4795.
