台灣專家顧問－沈立言 先生

【現職】
．生物資源暨農學院 食品科技研究所 特聘教授
．生物資源暨農學院 食品與生物分子研究中心 中心主任

【學歷】
．國立中興大學 食品科學系 學士
．國立中興大學 食品科學研究所 碩士
．國立中興大學 食品科學研究所 博士

【經歷】
．國立臺灣大學 國家食品安全教育暨研究中心
．國立臺灣大學 健康科學與生活研究中心
．國立臺灣大學 食品與生物分子研究中心
．互補暨整合醫學組
．臺灣食品保護協會 (國際食品保護協會-臺灣分會)
．International Association for Traditional and Complementary Medicine
．臺灣傳統暨替代醫學協會
．Journal of Traditional and Complementary Medicine
．ISRN Toxicology Journal
．Journal of Food and Drug Analysis
．European Journal of Toxicological Sciences
．台灣保健食品學會

【榮譽】
．臺灣保健食品學會傑出學術研究獎
．臺灣大學 特聘教授
．臺灣大學 校級教學傑出教師
．臺灣營養學會 營養學術研究傑出獎
．榮登Who’s Who in Medicine and Healthcare, 2009-2010 (Marquis Who’s Who, USA)
．臺灣食品科技學會 食品學術研究榮譽獎
．臺灣農業化學會 學術榮譽獎

【期刊論文】 (近三年 since 2013, *corresponding author)

1. Lin, Y.E., Lin, S.H., Chen, W.C., Ho, C.T., Lai, Y.S., Panyod, S., and Sheen, L.Y.* 2016. Antidepressant-like effects of water extract of Gastrodia elata Blume in rats exposed to unpredictable chronic mild stress via modulation of monoamine regulatory pathways. Journal of Ethnopharmacology. (SCI, Revised)
2. Lai, Y.S., Lee, W.C., Lin, Y.E., Ho, C.T., Lu, K.H., Lin, S.H., Panyod, S., Chu, Y.L., and Sheen, L.Y.* 2016. Ginger essential oil ameliorates hepatic injury and lipid accumulation in high fat diet-induced nonalcoholic fatty liver disease. Journal of Agricultural and Food Chemistry. (SCI, Accepted)
3. Chen, W.C., Lai, Y.S., Lin, S.H., Lu, K.H., Panyod, S., Ho, C.T., and Sheen, L.Y.* 2016. Anti-depressant effects of Gastrodia elata Blume and its compounds, gastrodin and 4-hydroxybenzyl alcohol, involve the monoaminergic system and neuronal cytoskeletal remodeling processes. Journal of Ethnopharmacology. (SCI, Accepted)
4.   Lin, J.G., Lu, K.H., and Sheen, L.Y.* 2016. Dietary therapy in traditional Chinese medicine: Ancient wisdom as preventive medicine.   
5. Science. (SCI, Accepted)
6. Lin, S.H, Chou, M.L., Chen, W.C., Lai, Y.S., Lu, K.H., Hao, C.W., Chu, Y.L., and Sheen, L.Y.* 2015. Antidepressant-like activity of the water extract of Melissa officinalis L. in forced swimming test via regulation of the serotonergic neurotransmitter. Journal of Ethnopharmacology. (SCI, In press)
7. Lai, Y.S., Chen, W.C., Kuo, T.C., Ho, C.T., Kuo, C.H., Tseng, Y, Lu, K.H., Lin, S.H. Panyod, S., and Sheen, L.Y.* 2015. Mass spectrometry-based serum metabolomics of a C57BL/6J mouse model of high-fat diet induced nonalcoholic fatty liver disease development. Journal of Agricultural and Food Chemistry 63(35): 7873-7884. (SCI)
8. Chang, H.P., Sheen L.Y., and Lei, Y.P. 2015. The protective role of carotenoids and polyphenols in patients with head and neck cancer. Journal of the Chinese Medical Association 78(2): 89-95. (SCI)
9. Huang, L.Y., Chu, Y.L., Ho, C.T., Chung, J.G., Lai, C.I., Su, Y.C., Kuo, Y.H.*, and Sheen, L.Y. *2015. Antcin K, an active triterpenoid from the fruiting bodies of basswood cultivated antrodia cinnamomea, inhibits metastasis via suppression of integrin-mediated adhesion, migration, and invasion in human hepatoma cells. Journal of Agricultural and Food Chemistry 63(18): 4561-9456. (SCI)
10. Wu, W.K., Panyod, S., Ho, C.T., Kuo, C.H., Wu, M.S., and Sheen, L.Y.* 2015. Dietary allicin reduces transformation of L-carnitine to TMAO through impact on gut microbiota. Journal of Functional Foods 15: 408-417. (SCI)
11. 盧冠宏、沈立言*。2015。面對食安風暴，民眾該如何自保。司法新聲 113: 25-29。
12. Chen, W.C., Lai, Y.S., Lu, K.H., Lin, S.H., Liao, L.Y., Ho, C.T., and Sheen, L.Y.* 2015. Method development and validation for the HPLC assay of gastrodin in water extracts from different sources of Gastrodia elata Blume. Journal of Food and Drug Analysis 23(4): 803-810. (SCI)
13. Cheng, B.H., Sheen, L.Y., and Chang, S.T. 2015. Evaluation of anxiolytic potency of essential oil and S-(+)-linalool from Cinnamomum osmophloeum ct. linalool leaves in mice. Journal of Traditional and Complementary Medicine 5(1): 27-34.
14. 盧冠宏、潘怡君、沈立言*。2016。臺灣食品安全事件的省思-從危機處理提升至風險管理 (中國飲食文化)。臺灣人文學引文索引核心期刊。(In press)
15.  Lo, W.Y., Sheen, L.Y., Lo, Y.C., and Hsieh, S.C. 2014. The effects of blackcurrant on anti-inflammation and prevention of allergicrespiratory diseases syndrome. Taiwanese Journal of Agricultural Chemistry and Food Science 52(1): 25-30.
16. Chen, P.B., Wang, H.C., Liu, Y.W., Lin, S.H., Chou, H.N., and Sheen L.Y.* 2014. Immunomodulatory activities of polysaccharides from Chlorella pyrenoidosa in a mouse model of Parkinson’s disease. Journal of Functional Foods 11: 103-113. (SCI)
17. Lin, S.H., Chen, W.C, Lu, K.H., Chen, P.J., Hsieh, S.C. Pan, T.M., Chen, S.T., and Sheen, L.Y.* 2014. Down-regulation of slit-robo pathway mediating neuronal cytoskeletal remodeling processes facilitates the antidepressive-like activity of Gastrodia elata Blume. Journal of Agricultural and Food Chemistry 62(43): 10493-10503. (SCI)
18.  Lai, Y.S., Chen, W.C., Ho, C.T., Lu, K.H., Lin, S.H., Tseng, H.C., and Sheen, L.Y.* 2014. Garlic essential oil protects against obesity triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress. Journal of Agricultural and Food Chemistry 62(25): 5897-5906. (SCI)
19.  Liu, Y.T., Lo, Y.C., Hsieh, S.C., and Sheen, L.Y.* 2014. The antioxidant activity of blackcurrant and its effects on Parkinson’s disease and Alzheimer’s disease. Nutritional Science Journal 38(4): 120-131.
20.  Lu, K.H., Tseng, H.C., Liu, C.T., Huang, C.J., Chyuanc, J.H., and Sheen, L.Y.* 2014. Wild bitter gourd protects against alcoholic fatty liver in mice by attenuating oxidative stress and inflammatory responses. Food and Function 5(5): 1027-1037. (SCI)
21. Liu, C.T., Raghu, R., Lin, S.H., Wang, S.Y., Kuo, C.H., Tseng, Y.J., and Sheen, L.Y.* 2013. Metabolomics of ginger essential oil against alcoholic fatty liver in mice. Journal of Agricultural and Food Chemistry 61(46): 11231-11240. (SCI)
22. Chu, Y.L., Chimeddulam, D., Sheen, L.Y, and Wu, K.Y. 2013. Probabilisticrisk assessment of exposure to leucomalachite green residues from fish products. Food and Chemical Toxicology 62: 770-776. (SCI)
23. Chu, Y.L., Ho, C.T., Chung, J.G., Rajasekaran R., Lo Y.C., and Sheen, L.Y.* 2013. Allicin induces anti-human liver cancer cells through p53 gene modulating apoptosis and autophagy. Journal of Agricultural and Food Chemistry 61: 9839-9848. (SCI)
24. Chu, Y.L., Rajasekaran, R., Lu, K.H., Liu, C.T., Lin, S.H., Lai, Y.S., Chen, W.C., Lin, S.H., and Sheen, L.Y.* 2013. REVIEW ARTICLE: Autophagy Therapeutic Potential of Garlic in Human Cancer Therapy. Journal of Traditional and Complementary Medicine 3(3): 159-162.
25. Chen, S.F., Hu, T.M., Lan, T.H., Chiu, H.J., Sheen, L.Y.*,and Loh, E.W. 2013. Severity of psychosis syndrome and change of metabolic abnormality in chronic schizophrenia patients: Severe negative syndrome may be related to a distinct lipid pathophysiology. European Psychiatry 29(3): 167-171. (SCI)
26. Lin, S.H., Chang, H.C., Chen, P.J., Hsieh, C.L., Su, K.P., and Sheen, L.Y.* 2013. The antidepressant-like effect of ethanol extract of daylily flowers (金針花 Jīn Zhēn Huā ) in rats. Journal of Traditional and Complementary Medicine 3(1): 53-61.
27. Hao, C.W., Lai, W.S., Ho, C.T., and Sheen, L.Y.* 2013. Antidepressant-like effect of lemon essential oil is through a modulation in the levels of norepinephrine, dopamine, and serotonin in mice: use of the tail suspension test. Journal of Functional Foods 5: 370-379. (SCI)